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Block copolymers can be formulated into micelles, nanoparticles and vesicles. These structures can be modified to act as agent delivery systems. Polymer blocks with unique spectrally distinguishable units are used, which enable investigations by means of TERS experiments. As such we address the homogeneity of the formed core and shell/corona and study the interaction of these nanostructures with proteins of body fluids. TERS measurements are supplemented by means of AFM adhesion and elasticity investigations. This multimodal approach provides the perspective to further understand the uptake mechanisms of polymer nanoparticles, vesicles and micelles in cellular environments..
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